PGT Impact
PGT worldwide experience includes hundreds of thousands PGT cycles performed by more than 100 centers around the world. The majority of PGT (more than three thirds of cycles) were for aneuploidy, the remaining one third for Mendelian disorders and translocations. An increasing number of cases (over 2,000) is being performed for preimplantation HLA typing. PGT impact on assisted reproduction and genetic practices:
Reduces
Risks
allows at risk couples to avoid birth of child with Mendelian disease
Improves
Success Rate
improves implantation and take home baby rates in poor prognosis IVF patients
Reduces
Defects
reduces five-fold spontaneous abortions in carriers of chromosomal rearrangements
Reduces
Disorders
allows forgoing pregnancy for couples at risk for producing offspring with late-onset disorders with genetic predisposition
Allows
Matching
allows producing an HLA matched offspring for treatment of siblings requiring HLA matched stem cells transplantation
Improves
Practices
improves standards of assisted reproduction technologies and genetic practices